Estimation of gene-environment interaction by pooling biospecimens
نویسندگان
چکیده
منابع مشابه
A Gene-Environment Interaction
Background—Particulate air pollution has been associated with cardiovascular mortality and morbidity. Transition metals such as iron bound to the particles may be responsible for those associations. The protein product of the hemochromatosis (HFE) gene modulates uptake of iron and divalent cations from pulmonary sources and reduces their toxicity. Two HFE polymorphisms (C282Y and H63D) associat...
متن کاملestimation of genotype by environment interaction for production traits in iranian holstein cattle
in order to evaluation of genotype by environment interactions in holstein cows, iran was divided into cold, middle cold, temperate and hot climate regions. for this purpose used from 39570, 35813 and 18955 records for milk, fat and protein yields, respectively, to progeny test for 35 sires that have 50 daughters in each climate. the data were collected by the centre of breeding and improvement...
متن کاملFrom Genotype × Environment Interaction to Gene × Environment Interaction
Historically in plant breeding a large number of statistical models has been developed and used for studying genotype × environment interaction. These models have helped plant breeders to assess the stability of economically important traits and to predict the performance of newly developed genotypes evaluated under varying environmental conditions. In the last decade, the use of relatively low...
متن کاملGene–Environment Interaction in Yeast Gene Expression
The effects of genetic variants on phenotypic traits often depend on environmental and physiological conditions, but such gene-environment interactions are poorly understood. Recently developed approaches that treat transcript abundances of thousands of genes as quantitative traits offer the opportunity to broadly characterize the architecture of gene-environment interactions. We examined the g...
متن کاملSpecimen pooling for efficient use of biospecimens in studies of time to a common event.
For case-control studies that rely on expensive assays for biomarkers, specimen pooling offers a cost-effective and efficient way to estimate individual-level odds ratios. Pooling helps to conserve irreplaceable biospecimens for the future, mitigates limit-of-detection problems, and enables inclusion of individuals who have limited available volumes of biospecimen. Pooling can also allow the st...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Statistics in Medicine
سال: 2012
ISSN: 0277-6715
DOI: 10.1002/sim.5357